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These pathological aggregates of insoluble protein primarily consist of hyper-phosphorylated tau and misfolded amyloid- isoforms in conjunction with metals, which may result in vascular dysregulation (due to injury to the endothelial lining of the vascular rings), and OS, which triggers the progression of AD (Perry et al., 2002)

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98 Their study also demonstrated that the expression levels of GRP78 and IRE1 were increased in a dose-dependent manner after the treatment of dimethylchrysin

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Targeting oxidative stress in central nervous system disorders