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Physiol Plant 115:531540 Ruiz-Torres C, Feriche-Linares R, Rodrguez-Ruiz M, Palma JM, Corpas FJ (2017) Arsenic-induced stress activates sulfur metabolism in different organs of garlic ( Allium sativum L.) plants accompanied by a general decline of the NADPH-generating systems in roots

Although this region of the enzyme has been confirmed to bind GSH and the C28-C31 pair has been observed to be necessary for the reduction of GSSG, there is no explicit evidence of how electrons are transmitted to the GR domain

Subsequent in vivo studies demonstrated that Fe 3 O 4 @PCBMA-SIM markedly suppressed tumor growth while maintaining a favorable safety profile

Existing reviews tend to fall into two categories: overly broad analyses that emphasize reactive oxygen species (ROS) biology without sufficiently addressing GSH, or highly focused discussions on chemical linkers that overlook translational relevance

10.3390/molecules22040555 Summary Keywords l-arginine, nitric oxide, cGMP, K ATP , cardiovascular disease, metabolic syndrome, pain, phytochemicals Citation Hosseini SZ, Abbaszadeh F, Alavi SD, Gravandi MM, Amirian R, Fakhri S and Echeverra J (2025) Targeting L-arginine/NO/cGMP/K ATP pathway by phytochemicals: therapeutic applications and clinical perspectives

Anal Biochem 49:474478