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This is the window that the Finkley 2005 trial captured, and the Carey/Pickart ultrasound work confirmed at the structural level: an average 28% increase in collagen density, with top responders at 51%

There is a theoretical case for using both in certain patients, targeting different physiological mechanisms simultaneously, though this approach is under evaluation and not yet standard of care

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Other new agents are undergoing clinical trials, such as MOR202 (Felzartamab) (fully human) [59], TAK079 (Mezagitamab) (fully human) [60], FTL004 (humanized Ig1) [61], SAR442085 (fully human engineered) [62] and TNB-738 (fully human) [63]