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However, no research directly compares continuous use versus cycling protocols (such as 12 weeks on, 4-8 weeks off), leaving optimal long-term strategies somewhat uncertain

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Furthermore, large-scale clinical trials are needed to evaluate the efficacy and safety of microbiome-targeted interventions, such as probiotics, prebiotics, dietary modulation, and fecal microbiota transplantation (104)

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Bone marrow was collected by rinsing the bone inner cavity with Dulbeccos modified Eagles medium (DMEM) containing 10% fetal bovine serum (FBS), 2% glutamate, and 1% penicillin

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