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Taken together, these functional modules collectively support the core mechanism that a healthy intestinal microbiota maintains immune and joint homeostasis, whereas dysbiosis impairs the intestinal barrier, triggers systemic inflammation, and promotes the progression of rheumatoid arthritis, in which traditional Chinese medicine can exert intervention effects by modulating the microbiota and intestinal barrier

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The follow-up duration and hard endpoints are also insufficient: the median duration in phase III studies is 48 weeks, with no data on 2 years of mucosal maintenance or surgical rates, and the inclusion rate of hard endpoints is less than 10%

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The main functions are: Inositol improves ovarian activity, insulin sensitivity and fertility in patients with PCOS Inositol also decreases testosterone and is a marker of good egg quality N-Acetyl Cysteine: Nutritional supplement N-Acetyl Cysteine, also known as NAC