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The novel triple monoamine reuptake inhibitor tesofensine induces sustained weight loss and improves glycemic control in the diet-induced obese rat: comparison to sibutramine and rimonabant

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As a single agent in phase 2 dose-finding, cagrilintide produced dose-dependent weight loss of roughly 1011% at the highest dose over 26 weeks [4]

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Multiple reaction monitoring mode was used for compounds quantification