interaction of chloroacetamide electrophiles with cellular glutathion Covalent inhibitors bacterial peptidoglycan biosynthesis enzyme MurA warhead Design, synthesis, and biological evaluation

Design, synthesis, and biological evaluation of nitroisoxazole containing spiro[pyrrolidin oxindole] derivatives as novel glutathione peroxidase 4 mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation ScienceDirect Glutathione Dynamics in Subcellular Compartments and Implications for Drug Development PMC Electrophilic compound screening identifies GPX4 dependent ferroptosis as a senescence vulnerability Nature Cell Biology Delineating cysteine reactive compound modulation of cellular proteostasis processes Nature Chemical Biology Overexpression of Glutathione S Transferases in Human Diseases: Drug Targets and Therapeutic Implications Formation of protein derived electrophiles in ribonuclease A by biologically relevant oxidants ScienceDirect

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