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Timing: Morning or before bed on an empty stomach

In obese rodent models, it promotes lipolysis by breaking down stored fats into free fatty acids without stimulating GH pathways such as IGF-1

NNMT is upregulated in the white adipose tissue of obese animals and humans, and its activity is mechanistically linked to depleted cellular NAD+ and SAM pools

Put plainly, the off period is not there because the compound stops working it is there because no one can point to human data showing that running it indefinitely is safe, and a scheduled break is the honest way to respect that gap