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10.1093/jxb/eru258 J

In rectal cancer chemoradiotherapy and metastatic renal cell carcinoma combinations, CRLX101 has produced signals consistent with vascular normalization and radiosensitization, although randomized trials have so far shown mixed results for hard outcomes such as progression-free survival [91, 92]

Weakened Immune System : The consequences of chronic sleep deprivation extend to the immune system, compromising its effectiveness

When intracellular oxygen availability is reduced (hypoxia), protein folding will be disturbed, leading to accumulation of misfolded or unfolded proteins

The dichotomy between necrosis in the ischemic core and apoptosis in the ischemic penumbra is not strict as apoptotic death has been also shown in the ischemic core and vice versa (Ontniente et al., 2003)

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