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115 In addition, liver insulin also effectively regulates lipid metabolism primarily by promoting cleavage and nuclear translocation of the sterol regulatory element binding protein 1c (SREBP-1c) 116,117 that activates lipogenesis in hepatocytes

Importantly, persistently high serum B12 in the absence of supplementation should prompt GP assessment, as it may indicate underlying disease processes

Here's a breakdown of what I can share based on available information: Key Facts and Mechanism Dual Agonist: Tirzepatide is the first-in-class dual GIP and GLP-1 receptor agonist

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