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In MNGIE, a loss of TP activity leads to the accumulation of deoxyuridine (dUrd) and thymidine (Thd), which infiltrate through the mitochondrial pyrimidine remedy pathway, leading to an imbalance of deoxyuridine triphosphate pool (dNTP)

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In this combination, dasatinib and quercetin effectively reduced the number of senescent cells in adipose tissue and the vasculature, while fisetin modulated the inflammatory SASP, improving overall tissue function and reducing the risk of age-related diseases such as cardiovascular disease and osteoporosis.18 In another study, the combination of fisetin (a senolytic flavonoid) with sorafenib (a senomorphic agent) showed better synergistic effects in vitro and in vivo than either agent used alone against human cervical cancer.218 These findings highlight the potential of combination therapies to improve multiple aspects of aging simultaneously, rather than focusing on a single target

& Chan, L