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A 2025 systematic review and meta-analysis of 12 studies (6,645 participants) confirmed significant correlations between klotho levels and cognitive function, supporting its potential as both biomarker and therapeutic target

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And critically for obesity research, it acts centrally: amylin binds to receptors in the area postrema and the brainstem, where it generates satiety signals that communicate to the brain that the body has had enough to eat