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Hydrophobic BAs, such as chenodeoxycholic acid (CDCA) and deoxycholic acid (DCA), have been shown to impair epithelial barrier function by disrupting the expression and structural integrity of tight junction proteins, including Occludin, ZO-1, and Claudins 151

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For example, it might increase the number of growth hormone receptors on the cell surface, allowing the cells to respond better to the growth hormone signals

doi: 10.1016/j.cell.2020.10.044 332 CeramiEGaoJDogrusozUGrossBESumerSOAksoyBAet al

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