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Combined effects of glutathione S -transferase polymorphisms and thyroid cancer risk
Reddy SM, Reuben A, Barua S, Jiang H, Zhang S, Wang L , Gopalakrishnan V, Hudgens CW, Tetzlaff MT, Reuben JM, Tsujikawa T, Coussens LM, Wani K, He Y, Villareal L, Wood A, Rao A, Woodward WA, Ueno NT, Krishnamurthy S, Wargo JA, Mittendorf EA
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GGTs Role in the Body GGT is a vital enzyme involved in recycling and managing glutathione (GSH), the most abundant water-soluble antioxidant in cells, essential for many key functions in plants, animals, and humans 14 15
Network modeling Graph neural networks and other advanced computational tools now enable simulations wherein perturbation of a single node, for example, HSP90 inhibition, can be computationally modeled to predict downstream shifts in UPS engagement or autophagy induction