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Interestingly, FSP1 has been redefined as a vital factor dependent on N-myristoylation, which enables FSP1 to anchor in the membrane where FSP1 plays an anti-ferroptosis role by counteracting lethal phospholipid peroxidation dependent on its oxidoreductase activity (Bersuker et al

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which agrees with the recent work

PrP has several histidine (H)-containing Cu-binding sites in its N-terminal octapeptide repeat (OR) region and in the more distal non-OR region 25,26,29

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Each stage of decline amplifies comorbid risk, making proactive strategies essential