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KEGG enrichment analysis was performed by KOBAS 2.1.1 ( Besides, proteinprotein interactions of genes were analyzed by Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) algorithm ( Quantitative real-time PCR and Western blot analysis The total RNA from kidney tissue was extracted using Trizol Reagent

GPX4, originally known as PHGPX (phospholipid hydroperoxide glutathione peroxidase), was initially purified in porcine liver or heart in 1982 as a peroxidation-inhibiting protein on liposomes and biological membranes in the presence of glutathione (GSH) [10]

Importantly, Set7/9-dependent methylation of -catenin is enhanced under oxidative stress conditions, thus forming a regulatory mechanism for the WNT/-catenin signaling during the oxidative stress response [132]

Proteomics 2008;8(2):402-412

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[DOI] [PMC free article] [PubMed] [Google Scholar] 72.Bruehl S., Burns J.W., Gupta R., Buvanendran A., Chont M., Orlowska D., Schuster E., France C.R