In one intriguing study from the Mayo Clinic, 10 out of 44 (23%) patients diagnosed with CBS had a history of limb immobilization or trauma in the most affected limb [ 20 ]

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B12 plays a vital role in DNA production and the production of brain, nerve, and red blood cells
Finally, if the serum cobalamin concentration at the time of reevaluation is subnormal, further work-up is required to definitively diagnose the underlying disease process and cobalamin supplementation should be continued weekly or bi-weekly (for parenteral supplementation) or daily (for oral supplementation)
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This is a practical choice that keeps injection volumes small while fitting within standard vial capacity