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Quercetin is a polyphenol belonging to the flavonoid group found in vegetables and fruits and significantly reduces ROS, neuroinflammation, anxiety risk, and stress-related mood swings [129]

Pathway crosstalk and contextual redundancy Mitophagy pathways exhibit redundancy and may interact with each other or be distinctly necessary in response to specific stress

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To date, the US Food and Drug Administration and Health Canada have approved 7 ICI (and 1 combination), which target either CTLA-4 or PD-1/PD-L1 pathways for a variety of different cancers (Table 1) 7

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