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Science 265 , 18831885 (1994)

Manage expectations from the start

The pineal gland also produces several bioactive peptides and neurotransmitters that influence everything from immune function to reproductive hormones to oxidative stress defense

The 5-Amino-1MQ half life directly informs this strategy

Daver N, Alfayez M, Garcia-Manero G, Abbas H, Basu S, Konopleva M, Jabbour E, Cortes JE, Ravandi F, Kadia TM, DiNardo C, Assi R, Pierce S, Andreeff M , Estrov ZE, Pemmaraju N, Takahashi K, Ning J, Gonzalez NG, Kornblau SM, Matthews J, Flores WR, Allison JP, Sharma P, Kantarjian H