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Moreover, combination therapies may further enhance the DHODH-inhibition strategy efficacy

doi: 10.1016/j.freeradbiomed.2014.07.046 34 OuerdSIdris-KhodjaNTrindadeMFerreiraNSBerilloOCoelhoSCet al

Experts increasingly advocate aligning safety expectations for high-risk probiotic products (e.g., LBPs) with those applied to other complex biologicals, including systematic genomic characterization, standardized adverse-event reporting, and structured post-market surveillance, while avoiding unnecessarily stricter requirements than for comparable biologic therapies (525)