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doi:10.1016/S0026-0495(96)90171-7

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We are also finalizing paragraph (a) of 425.640, as proposed, to describe the purpose of the payment option: prepaid shared savings provide an additional cash flow option to ACOs with a history of earning shared savings that will encourage their investment in activities that reduce costs for the Medicare program and beneficiaries and improve the quality of care provided to their assigned beneficiaries

Since no human clinical trials exist, these numbers are based on animal research and years of community experience

Additionally, participant attrition occurred in both groups (six in the NW group and five in the EBW group), which reduced the final sample size and may have compromised the statistical power, particularly in the specific methylation analyses