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Lipsticks, lip liners, and toothpastes containing certain fragrances or preservatives can trigger pigmented contact cheilitis, a low-grade inflammatory reaction that deposits pigment without obvious redness or pain

Another study revealed that alcohol consumption is related to change in plasma sex hormone levels in premenopausal women (Reference Sarkola, Mkisalo and Fukunaga38)

Still, it influences the release of TGF-1, the activation and proliferation of fibroblasts, and their differentiation into myofibroblasts, mostly mediated by the RANKL/NF-B pathway

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The reduced IGF-1 effect observed in men on antiestrogens may be explained by the known role of estrogen in stimulating growth hormone secretion through both feedforward drive and reduction of somatostatin feedback