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doi: 10.1021/acs.jafc.0c04604 [DOI] [PubMed] [Google Scholar] 186.Shippy DC, Wilhelm C, Viharkumar PA, Raife TJ, Ulland TK

In an open-label, rater-blinded, single-dose crossover study, IPX203 treatment led to levodopa plasma concentrations larger than 50% of the maximum concentration for 4.6 h compared to 3.9 h with IPX066 accompanied by an increase in good ON-time measured with the Investigator Assessment of Subject's Motor State (5.3 h for IPX203 vs 4.5 h for IPX066) [21]

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TABLE 5 The targets and mechanisms of antidepressant effect of VOA

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