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NB100-417

Blood 107, 49074916

The PLC-mediated release of inositol trisphosphate, IP 3 (from membrane-associated phosphatidylinositol-4,5-bisphosphate, PIP 2 ), leads to the release of intracellular stores of Ca 2+

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However, apoptosis, necroptosis, ferroptosis, pyroptosis, cuproptosis, PANoptosis, NETosis, autophagy-dependent cell death, mitotic death, mithuosis, alkaliptosis, anoikis, autosis, disulfidptosis, entosis, oxeiptosis, and parthanatos are reported as distinct RCD modes with unique signal transduction pathways (Fig

Since initial seeding was uniform, the observed increase in total RLU reflects the net accumulation of ROS, which we believe is the primary driver of the anti-tumor response