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Importantly, this metabolic adaptation did not correlate with a diminution of mitochondrial function, indicating that acute exposure to high glucose triggers a robust and synergistic activation of both glycolytic and oxidative pathways (Esen and Long 2014)

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doi: 10.3389/fphar.2025.1606804 Received 06 April 2025 Accepted 27 June 2025 Published 15 July 2025 Volume 16 - 2025 Edited by Venkatesh Pooladanda, Harvard Medical School, United States Reviewed by Lopmudra Sarode, Nagpur Veterinary College, India Sreelakshmi Badavenkatappa Gari, Jawaharlal Nehru Technological University, India Updates Copyright 2025 Shi, Lu, Wei, Ma, Li, Li, Wang, Wang, Xu and Cui

To compensate for this sudden loss of blood pressure, the autonomic nervous system triggers severe tachycardia (a rapid heart rate), manifesting as Postural Orthostatic Tachycardia Syndrome (POTS) and other forms of dysautonomia

So while this comparison raised questions about how the treatment stacks up against competitors, it doesnt necessarily affect its chances of approval