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Description

Cholesterol accumulation can also lead to demyelination, as seen in Cerebrotendinous Xanthomatosis, caused by mutations in the sterol 27-hydroxylase gene ( CYP27A1 ) 129,130

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[5] The production of free radicals is in equilibrium with the action of the antioxidant protective system

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[PMC free article: PMC2795667] [PubMed: 19890023] 68

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Preclinical assessments of the MEK inhibitor PD-0325901 in a mouse model of Neurofibromatosis type 1

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