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The synthetic version used in research is a stable fragment of this naturally occurring compound

Mutations in these genes result in impaired mitophagy and inflammatory responses, leading to the accumulation of abnormally aggregated proteins, exacerbating neuronal damage, and causing peripheral neuropathy and autonomic dysfunction

Malar J 22:125

IGF1-LR3, thanks to its long half-life, is highly effective in counteracting myostatin and appears to work by activating a muscle protein called MyoD [1], [2]