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Clinical trials testing Crizanlizumab efficacy have yielded promising results in which a high dose (5 mg/kg) is shown to significantly decrease the pain crisis rates (Ataga et al., 2017)

Since AAS use is still very popular, the users self-administer post-cycle drugs after an AAS cycle to mitigate the side effects

For example, the combination of a KDM5B inhibitor and lenvatinib can restore p15 levels and enhance the sensitivity of resistant cells to lenvatinib [220]