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ATF4 transcription plays a key role in maintaining cellular homeostasis, thereby promoting cellular adaptation

Tops initiated partly the cell recovery following the cell mortality by tert -butyl hydroperoxide, which showed other relevant mechanisms rather than PI3K/Akt and HO-1 were responsible for Tops initiated cell recovery[]

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Emerging evidence implicates a key role for non-mutational drug resistance mechanisms underlying the survival of residual cancer persister cells 2,3,4