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Intranasal delivery extends the effective CNS half life because the peptide is transported directly along olfactory and trigeminal nerve pathways into cerebrospinal fluid and hippocampal interstitial space, bypassing systemic circulation and hepatic metabolism

Oral formulations of GLP-1 agonists exist but show reduced efficacy compared to injectable versions

These include dysregulation of nutrient sensing, mitochondrial dysfunction, and cellular senescence (Fig

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Dosage, Concentration, Route of Administration Dosage: Seek advice from a licensed physician, medical director, or other healthcare provider Concentration: 0.9mg/ml Route of administration: IM/SubQ Resources: Tutorial: How to Give a Subcutaneous Injection Tutorial: How to Open Your Medication Vial Sermorelin Dosage Chart Precautions/Side Effects Like any medication, sermorelin peptide may cause side effects

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