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During endotoxemia, NF-B and Wnt/-catenin signaling are mutually activated, and -TrCP mediates the degradation of IB to upregulate NF-B signaling

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Transmembrane protein 198 promotes LRP6 phosphorylation and Wnt signaling activation

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However, none of the cytokines influenced PD-1 expression on CIK cells (Fig