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Even during the prodromal period, when LRRK2 expression in the colon is noticeably raised, increased expression of LRRK2 has been observed in colon biopsies from PD patients, with expression levels corresponding with disease severity (98)

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Introduction Liver cirrhosis poses a substantial disease burden worldwide due to its increased probability of developing serious complications, such as massive variceal bleeding, refractory ascites, and hepatorenal syndrome