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4 Neurotrophic factors and neuroprotective strategies 4.1 BDNF/TrkB signaling pathway The therapeutic relevance of the BDNF/TrkB pathway is further supported by TrkB agonist studies in noise-induced hearing loss models, which are highly relevant to tinnitus

Only four participants were recruited for the severe hepatic impairment group because of recruitment difficulties

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The maturation of germ cells is restricted, and apoptosis is increased ( 2.5.4 Oxidative stress and inflammation Prolonged hyperglycemia weakens antioxidant defenses and produces excessive ROS

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