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Consequently, oxidative stress has the potential to disrupt the equilibrium within melanocytes, causing significant metabolic disorders, including cells viability decrease or even their malignant metamorphosis 56

These disrupted cycles may resume when disease activity subsides or if the follicle manages to remain in the anagen phase for a prolonged duration (Fig

Research findings showed that circOGDH silencing reduced ATP content, KG synthesis, glutamine consumption, and GLS1 protein level in ESCC cells, suggesting that circOGDH promoted glutamine metabolism in these cells