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Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

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In addition, lactate-induced lactylation stabilizes HIF-1 under normoxic conditions, facilitating its transcriptional activity on angiogenic targets (KlAA1199 axis) in prostate cancer cells and contributing to vascular remodeling [93]

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However, the specific mechanisms through which altered mitochondrial dynamics regulate DKD metabolism remain unknown and require further investigation

Using data from 569 OHD case families and 1,644 control families enrolled in the National Birth Defects Prevention Study (NBDPS) between 1997 and 2008, we conducted an analysis to investigate the genetic effects of 877 single nucleotide polymorphisms (SNPs) in 60 candidate genes associated with the risk of OHDs and their interactions with maternal use of folic acid supplements and prepregnancy obesity