mitochondrial glutathione depletion in Cellular Redox Homeostasis and Disease Manifestation Mitochondrial Glutathione: Regulation and Functions

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Moreover, antioxidant defense system failure exacerbates pathological progressiondeclining NAD+ in aging reduces SIRT1 activity, impairing mitochondrial repair 109 , whereas tumors upregulate glutathione systems to balance ROS, but excessive oxidative stress still causes genomic instability 104

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This nuclear presence of FOXO4 seems to be involved in maintaining the viability of senescent cells by possibly modulating downstream senescence-associated pathways, detailed by changes in p53, Ser15-phospho-p53, and p21 protein levels

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