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* Correspondence: Rocco Mollace [email protected] Roberta Macr [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

However, the exact regulatory pathway involved remains unknown[77]

Shen HM, Pervaiz S

Proinflammatory cytokines TNF- and IL1- activate the canonical NF-B pathway that induce the gene expression of cyclooxigenase-2, inducible nitric oxide synthase-3, inflammatory cytokines, and matrix metalloproteinases [75] These changes lead to the damage of TJs, decreased endothelial integrity and increased permeability at the BBB [73, 76], and to neuroinflammation and the development of chronic neurodegenerative diseases such as AD [10, 77]

Carotenoids Carotenoids are phytochemicals with antioxidant properties that can reduce the risk of cancer and cardiovascular disease

Key Dietary Tips While Taking Phentermine: Limit Caffeine: Phentermine can increase your energy and alertness, so adding large amounts of caffeine (from coffee, tea, energy drinks, or sodas) can heighten side effects like nervousness, jitteriness, elevated heart rate, or high blood pressure