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By contrast, in p21 KO cells, nutlin-3 treatment resulted in the differential expression of even more genes than observed in Control cells, consistent with the notion that p21 is itself an important transcriptional regulator (Fig 3A) (Delavaine & La Thangue, 1999

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The explanation may be that with advancing age and reaching old age, failure occurs in most of the cellular and physiological vital processes, and therefore the dopaminergic neurons do not play their natural role, which exposes them to damage and abnormal pathological effects

Implications for mechanisms mediating gender differences in drug abuse

A friend of mine who spoke German and English translated for me

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