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Methods OCTN2 protein expression and purification Full-length human wild-type OCTN2 (Uniprot accession: O76082) was synthesized and cloned into the pcDNA3.1 vector by Genscript

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It primarily consists of CD4+ lymphocytes, specifically Th2 cells, although Th1 cells and Th17 cell-derived cytokines are also found at increased levels in the blood (117)

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In terms of electrical remodeling, mitochondrial ROS decrease the activity of L-type Ca 2+ channels, resulting in a shortened action potential duration