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Ferroptosis and Its Mechanism Ferroptosis was first introduced in a study on the mechanism of some oncogenic RAS-selective lethal small molecule compounds, such as erastin and RSL3 in 2012 [24]

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For instance, 5 g/mL of grape seed extract (GSE) inhibited d-galactose-induced apoptosis in vitro , but higher concentrations (50 and 100 g/mL) of GSE and GSPB2 for 24 h reduced the survival rates of hGC cells and KGN cell lines by approximately 20% and 50%, respectively (Roberts et al., 2014)

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