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Joensen UN, et al

The maintenance of an electric potential across the inner mitochondrial membrane (negatively charged in the matrix) is necessary to power ATP synthase, and sustained decreases in MMP trigger mitophagy and overall decreases in cell viability [98]

CETSA is based on the principle that target proteins often become stabilized upon binding with small molecules, leading to a slower degradation rate under increasing temperatures [29]

doi: 10.1016/j.biotechadv.2018.09.003 56 YuYYangWBilottaAJZhaoXCongYLiY

A Phase II, Single-Center, Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Therapeutic Efficacy of Intranasal Glulisine in Amnestic Mild Cognitive Impairment and Probable Mild Alzheimers Disease