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152 National Institute for Health and Care Excellence [NICE] (2017)

38 For example, multiple doses of diltiazem 240 mg extended-release formulation, a strong CYP3A4 inhibitor and P-gp inhibitor, increased C max and AUC of naloxegol by 2.86-fold (90% confidence interval, 2.59, 3.15) and 3.41-fold (90% confidence interval, 3.16, 3.69), respectively

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