foxo4 dri senolytic or senomorphic FOXO4-DRI Peptide inhibitors targeting FOXO4-p53 interactions
Peptide inhibitors targeting FOXO4 p53 interactions and inducing senescent cancer cell specific apoptosis bioRxiv Targeting cellular senescence with senotherapeutics: senolytics and senomorphics Zhang 2023 The FEBS Journal Wiley Online Library FOXO4 DRI: Human Trial Status, Cancer Research & Senolytic Data FOXO4 DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53 serine 15 phosphorylation Communications Biology CHK2 USP37 axis stabilizes FOXO4 to sustain senescence and evade apoptosis PNAS Molecular modelling of the FOXO4 TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells eBioMedicine
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