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It accomplishes this by inhibiting the activity of prolyl hydroxylase (PHD) enzymes, so that they can no longer hydroxylate and destabilize HIF-1

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We proposed to estimate telehealth employee benefits by multiplying telehealth wages and salaries (as described in section III.B.7.(c)(1)(a)) of this final rule times the ratio of total direct patient care facility benefits (Worksheet S-3 part II, column 2, line 1) to total facility direct patient care salaries (the sum of Worksheet A, columns 1 and 2, lines 23 and 25 through 36), which is estimated to be 21 percent on average