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FOXO4-DRI is definitely an exciting piece of research to watch in the areas of anti-aging and anti-cancer.

Among the intrinsic factors are the sirtuins (SIRTs), a family of NAD + -dependent lysine deacetylases, some of which are exclusively expressed in mitochondria (SIRTs 3, 4, and 5) (Mattes et al., 2019)