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Conclusion: The new findings demonstrate the immunomodulatory role of DEX AFP-GPC3-N1ND in combination with PD-L1 monoclonal antibody during HCC immunotherapy and provide a basis for the formulation of DEX vaccines targeting hepatocellular carcinoma, providing a scalable approach for personalized immunotherapy of HCC that can be extended to other tumors without the need to identify tumor antigens

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Int J Mol Sci 23(20):12663

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