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The effect of carnitine in patients using artificial pacemakers

In children, episodes may last for several hours or even several days

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doi: 10.17219/acem/61609 [DOI] [PubMed] [Google Scholar] 70

CrAT deficiency leads to accumulating acetyl-CoA, which exerts an allosteric inhibiting effect on pyruvate dehydrogenase (PDH), a rate-limiting enzyme for pyruvate entry into the Krebs cycle