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Other indolent lymphomas, such as nodal MZL and lymphoplasmacytic lymphoma, can also harbor distinct genetic alterations such as MYD88 and L265P mutations, implicated in promoting survival through constitutive NF-B activation ( Table 3 Summary of indolent non-Hodgkin lymphoma and associated genetic aberration ( Follicular lymphoma In FL, genetic mutations occur in epigenetic regulators such as KMT2D or CREBBP in roughly two-thirds of patients ( EZH2 , ARID1A , MEF2B , EP300 , FOXO1 , CREBBP , and CARD11 , providing a more nuanced risk stratification that guides therapeutic decisions and identifies patients who may benefit from more aggressive treatment strategies ( vs