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(2022) first revealed age-dependent changes in H 2 S-metabolizing enzymes in the intestinal mucosa: healthy adults had significantly lower expression of key enzymes like SQOR and 3-MST in the intestinal lining than children, suggesting that H 2 S detoxification capacity naturally declines with age

The 4-PBA group showed mild sinusoidal congestion with focal hepatocyte necrosis as manifested by nuclear pyknosis, karyorrhexis, and karyolysis with cytoplasmic eosinophilia (Figure 8A), yet it significantly attenuated histopathological scoring compared to MTX-group (Figures 8BD)

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It also improves blood flow and angiogenesis, which helps with tissue repair