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Description

Excessive copper impairs intrahepatocyte trafficking and secretion of selenoprotein P

The genotype of the modified strain at the GSH1 locus was checked by PCR after 50 generations growth in the presence of 100 g/ml 5-FOA

Dexter DT et al

[26], resulting in (1) underestimation of the impact of APAP on the incidence ofASD and (2) a lack of statistical power leading to confidence intervals that are too large to draw conclusions [2]

Nat Genet 2005

One explanation for this is attributed to the feedback regulation within the pathwaycontinuous NRF2 activation triggers the cellular program to express NRF2 transcriptional repressors (Figures 4A,B)